Significance of glucose intolerance and SHIP2 expression in hepatocellular carcinoma patients with HCV infection

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Significance of glucose intolerance and SHIP2 expression in hepatocellular carcinoma patients with HCV infection.

Glucose intolerance frequently is found in hepatocellular carcinoma (HCC) patients with hepatitis C virus (HCV) infection; however, the significance of glucose intolerance remains unclear. In addition, SH2 domain-containing inositol phosphatase (SHIP) 2 is a negative regulator of intracellular insulin signaling; however, changes in SHIP2 expression have not been investigated in HCC. To assess t...

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Serum biomarkers for early detection of hepatocellular carcinoma associated with HCV infection in egyptian patients.

BACKGROUND Early detection of hepatocellular carcinoma using serological markers with better sensitivity and specificity than alpha fetoprotein (AFP) is needed. AIMS The aim of this study was to evaluate the diagnostic value of serum sICAM-1, β-catenin, IL-8, proteasome and sTNFR-II in early detection of HCC. MATERIALS AND METHODS Serum levels of IL-8, sICAM-1, sTNFR-II, proteasome and β-ca...

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Status of serum alpha feto-protein (AFP) and midkine (MDK) levels in patients with hepatocellular carcinoma

Introduction: Hepatocellular carcinoma (HCC) is sixth common cancers worldwide and predominant in Asia and Africa. A number of evidence suggests a possible role of midkine (MDK) and α-fetoprotein (AFP) in the pathogenesis of hepatocellular carcinoma (HCC). Materials and methods: We studied MDK and AFP in patients with HCC or in healthy controls. MDK and AFP was measured by enzyme linked immuno...

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ژورنال

عنوان ژورنال: Oncology Reports

سال: 2007

ISSN: 1021-335X,1791-2431

DOI: 10.3892/or.18.3.545